/* Palette from minghaoguo.com; all page typography uses three sizes. */
:root {
  color-scheme: light;
  --paper: #fff;
  --ink: #2c3e50;
  --heading: #2c3e50;
  --muted: #6b747c;
  --blue: #3c78cd;
  --line: #eaecef;
  --soft: #f5f5f5;
  --accent: #e74c3c;
  --science: #51aa8e;
  --graphics: #da6457;
  --engineering: #5290d3;
  --prediction: var(--engineering);
  --structure: var(--graphics);
  --text: 18px;
  --subhead: 24px;
  --display: 40px;
  --font: Georgia, 'Times New Roman', serif;
}
* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 88px; }
body { margin: 0; background: var(--paper); color: var(--ink); font: var(--text)/1.5 var(--font); }
a { color: var(--blue); text-decoration: none; text-underline-offset: 4px; }
a:hover { text-decoration: underline; }
button, summary { font: inherit; }
button { cursor: pointer; }
a, button, summary, video { -webkit-tap-highlight-color: transparent; }
:focus-visible { outline: 2px solid var(--blue); outline-offset: 5px; }
img, video { display: block; max-width: 100%; height: auto; }
img { color: var(--muted); font-size: var(--text); }
figure { margin: 0; min-width: 0; }
p { margin: 0 0 .75em; }
h1, h2, h3 { color: var(--heading); font-family: var(--font); font-weight: 600; margin-top: 0; }
h1 { font-size: var(--display); }
sup { font-size: var(--text); line-height: 0; }
.page { width: min(1240px, calc(100% - 64px)); margin-inline: auto; }
.skip-link { position: fixed; z-index: 100; top: -80px; left: 16px; padding: 8px 14px; background: white; }
.skip-link:focus { top: 8px; }
.site-header { position: sticky; z-index: 20; top: 0; background: #fff; border-bottom: 1px solid var(--line); }
.header-inner { max-width: 1304px; min-height: 58px; margin: auto; padding: 10px 32px; display: flex; align-items: center; gap: 32px; }
.wordmark { font-size: var(--subhead); font-weight: 700; color: var(--heading); }
.site-header nav { display: flex; gap: 26px; margin-left: auto; font-size: var(--text); }
.site-header nav a { color: var(--muted); }
.site-header nav a[aria-current] { color: var(--blue); text-decoration: underline; }
.header-paper { padding-left: 25px; border-left: 1px solid var(--line); font-size: var(--text); }
.project-header { padding: 28px 0 24px; text-align: center; }
.project-header h1 { margin-bottom: 16px; }
.project-name { display: flex; justify-content: center; align-items: center; gap: 14px; font-size: var(--display); line-height: 1.12; letter-spacing: -2px; margin-bottom: 14px; }
.project-name img { object-fit: contain; width: 84px; height: 64px; }
.project-title { display: block; font-size: var(--display); letter-spacing: -.8px; line-height: 1.22; }
.authors { font-size: var(--text); line-height: 1.65; margin-bottom: 8px; }
.authors a { color: var(--ink); }
.authors a:hover { color: var(--blue); }
.project-title .title-loop { color: var(--science); white-space: nowrap; }
.project-title .title-emphasis { color: var(--accent); white-space: nowrap; }
.authors > span { display: inline-block; }
.affiliations { display: flex; flex-wrap: wrap; justify-content: center; gap: 1px 16px; font-size: var(--text); margin-bottom: 6px; }
.author-notes { display: flex; flex-wrap: wrap; justify-content: center; gap: 4px 18px; color: var(--muted); font-size: var(--text); line-height: 1.5; }
.author-notes span { white-space: nowrap; }
.resources { display: flex; flex-wrap: wrap; justify-content: center; gap: 10px; margin: 18px 0 22px; }
.resources a { background: var(--soft); padding: 5px 19px; border-radius: 3px; font-size: var(--text); }
.resources a:hover { background: #eaeef2; text-decoration: none; }
.abstract { max-width: 860px; margin: auto; font-size: var(--text); line-height: 1.5; text-align: left; }
.project-header .abstract { text-align: center; max-width: 820px; }
.hero-results { display: flex; justify-content: center; gap: 64px; margin-top: 22px; }
.hero-results a { display: flex; flex-direction: column; color: var(--ink); }
.hero-results strong { font-size: var(--display); font-weight: 400; color: var(--accent); }
.hero-results span, .hero-note { font-size: var(--text); color: var(--muted); }
.hero-note { margin: 10px 0 0; }

.research-section { padding: 36px 0; border-top: 1px solid var(--line); }
.first-section { margin-top: 24px; }
.section-heading { display: flex; align-items: baseline; justify-content: space-between; gap: 20px; margin-bottom: 18px; }
h2 { font-size: var(--subhead); line-height: 1.25; letter-spacing: -.45px; margin: 0; }
h3 { font-size: var(--subhead); line-height: 1.3; letter-spacing: -.3px; margin: 0 0 10px; }
.figure-reference { white-space: nowrap; font-size: var(--text); }
.section-intro { max-width: 850px; margin: -8px 0 18px; }
.small-note, .study-caption { display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 4px 20px; margin-top: 10px; align-items: baseline; }
.study-caption .variant, .study-caption .study-note, .study-caption .small-note { margin: 0; }
.study-caption .variant { font-weight: 600; }
.study-caption .study-note { grid-column: 1; }
.study-caption .variant ~ .study-note, .study-caption .small-note { grid-column: 1 / -1; }
.study-caption .figure-action { grid-column: 2; grid-row: 1; white-space: nowrap; }
.section-summary { display: grid; grid-template-columns: 300px minmax(0, 1fr); gap: 4px 28px; align-items: baseline; }
.section-summary h3 { grid-row: 1 / 3; margin: 0; }
.section-summary p { margin: 0; max-width: 68ch; }
.section-summary .small-note { grid-column: 2; }
.figure-note { color: var(--muted); font-size: var(--text); line-height: 1.5; }
.small-note { margin: 8px 0 0; }
.small-note a { white-space: nowrap; }
#prediction-references { display: flex; flex-wrap: wrap; gap: 4px 18px; }
.tabs { display: flex; flex-wrap: wrap; gap: 24px; border-bottom: 1px solid var(--line); margin-bottom: 16px; }
.tabs button { border: 0; border-bottom: 2px solid transparent; padding: 8px 0 10px; color: var(--muted); background: none; font-size: var(--text); font-weight: 700; line-height: 1.4; }
.tabs button[aria-selected=true] { color: var(--blue); border-bottom-color: var(--blue); }
.tabs button:hover { color: var(--blue); }
.method-panel, .structure-intro { display: grid; grid-template-columns: 1.7fr 1fr; gap: 28px; align-items: center; }
.method-panel.is-wide { grid-template-columns: 1fr; gap: 8px; }
.method-actions { text-align: right; font-size: var(--text); }
.method-copy p, .structure-intro p { font-size: var(--text); }
.method-copy { min-height: 225px; display: flex; flex-direction: column; justify-content: center; }
.modality-line { display: flex; flex-wrap: wrap; gap: 15px; font-size: var(--text); margin: 4px 0; }
.modality-line span { color: var(--engineering); border-bottom: 2px solid #cbdcf2; }
.modality-line span:nth-child(2) { color: var(--science); border-color: #c7e4da; }
.modality-line span:nth-child(3) { color: var(--graphics); border-color: #efccc7; }
.motion-media { position: relative; min-width: 0; aspect-ratio: 16 / 9; overflow: hidden; background: #fff; border: 1px solid var(--line); border-radius: 3px; }
.motion-media video { position: absolute; inset: 0; width: 100%; height: 100%; object-fit: contain; }
.motion-toggle { position: absolute; right: 10px; bottom: 10px; min-width: 50px; padding: 4px 10px; border: 1px solid var(--line); border-radius: 3px; background: #fffffff2; color: var(--blue); font-size: var(--text); line-height: 1.4; }
.motion-toggle:hover { background: var(--soft); }
.film-details { border-block: 1px solid var(--line); margin: 0; }
.film-details summary { cursor: pointer; color: var(--blue); padding: 12px 0; font-size: var(--text); }
.film-details summary span { color: var(--muted); font-size: var(--text); margin-left: 12px; }
.film-details[open] { padding-bottom: 16px; }
.film-details video { width: 100%; aspect-ratio: 16/9; border: 1px solid var(--line); background: white; }
.film-footer { display: flex; justify-content: space-between; gap: 20px; margin-top: 14px; font-size: var(--text); }
.film-chapters { display: flex; flex-wrap: wrap; gap: 16px; }
.film-chapters button { border: 0; background: none; padding: 0; color: var(--blue); font-size: var(--text); }
.film-chapters span { color: var(--muted); margin-left: 3px; }
.prediction-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 40px; }
.prediction-grid.expanded-prediction { grid-template-columns: 1fr; gap: 32px; }
.scaling-takeaway { display: flex; gap: 40px; margin-bottom: 8px; }
.scaling-takeaway span { color: var(--muted); font-size: var(--text); }
.scaling-takeaway strong { color: var(--prediction); font-size: var(--subhead); font-weight: 400; margin-right: 8px; }
.expanded-prediction .scaling-block { min-width: 0; }
.structure-intro.structure-wide { grid-template-columns: 1fr; gap: 16px; }
.scaling-block h3 { font-size: var(--subhead); padding: 0 0 10px; margin-bottom: 14px; border-bottom: 1px solid var(--line); font-weight: 400; }
.prediction-block .tabs { gap: 20px; }
.prediction-block .tabs button { font-size: var(--text); }
.chart-wrap { position: relative; min-width: 0; background: white; }
.chart-wrap canvas { display: block; width: 100%; max-width: 100%; }
.chart-replay { display: block; margin: 6px 0 0 auto; border: 0; background: none; color: var(--blue); padding: 0; font-size: var(--text); }
.chart-caption { font-size: var(--text); line-height: 1.5; margin: 10px 0 0; }
.chart-caption strong { font-weight: 600; }
.structure-intro { margin-bottom: 22px; }
.benchmark-panel { display: grid; grid-template-columns: 1.8fr 1fr; gap: 28px; align-items: center; }
.benchmark-copy h3 { font-size: var(--subhead); color: var(--prediction); }
.benchmark-panel[data-component="structure"] .benchmark-copy h3,
.structure-wide h3 { color: var(--structure); }
.benchmark-copy p { font-size: var(--text); }
.benchmark-copy .small-note { font-size: var(--text); }
.enzyme-grid { display: grid; grid-template-columns: 1fr; gap: 32px; }
.enzyme-study + .enzyme-study { border-top: 1px solid var(--line); padding-top: 26px; }
.study-heading { display: grid; grid-template-columns: 1fr auto; gap: 2px 24px; align-items: baseline; margin-bottom: 14px; }
.study-count { grid-column: 2; text-align: right; }
.study-heading h3 { font-size: var(--subhead); margin: 0; grid-row: 1 / 3; }
.study-heading h3 span { font-size: var(--text); color: var(--muted); display: block; margin-top: 3px; font-weight: 400; }
.result { font-size: var(--text); margin: 0; }
.result strong { display: inline-block; font-size: var(--display); line-height: 1.2; font-weight: 400; color: var(--accent); margin-right: 6px; }
.study-count { font-size: var(--text); color: var(--muted); margin: 0; }
.study-tabs { gap: 20px; margin-bottom: 16px; }
.study-tabs button { font-size: var(--text); }
.variant { margin: 16px 0 8px; font-size: var(--text); }
.study-note { font-size: var(--text); line-height: 1.5; margin: 14px 0 0; color: var(--muted); }
.study-note + .small-note { margin-top: 8px; }
.figure-note { margin: 18px 0 0; }
[hidden] { display: none !important; }
.citation-section { border-top: 1px solid var(--line); padding: 35px 0 25px; }
.citation-section h2 { font-size: var(--subhead); }
#copy-citation { border: 1px solid var(--line); border-radius: 3px; color: var(--blue); background: var(--soft); padding: 5px 12px; font-size: var(--text); }
pre { margin: 0; font: var(--text)/1.5 ui-monospace, SFMono-Regular, Consolas, monospace; white-space: pre-wrap; overflow-wrap: anywhere; background: var(--soft); padding: 19px 22px; border-radius: 3px; color: #526172; }
#copy-status { min-height: 23px; font-size: var(--text); color: var(--muted); margin: 5px 0 0; }
footer { display: flex; gap: 23px; border-top: 1px solid var(--line); padding: 23px 0 32px; font-size: var(--text); }
footer > span { font-weight: 600; }
.back-to-top { margin-left: auto; }

@media (max-width: 900px) {
 .page { width: calc(100% - 48px); }
 .header-inner { padding: 10px 24px; gap: 22px; }
 .site-header nav { gap: 17px; }
 .title-break, .author-break { display: none; }
 .project-title { font-size: var(--subhead); }
 .method-panel, .structure-intro, .benchmark-panel { gap: 20px; grid-template-columns: minmax(0, 1fr); }
 .method-copy { min-height: 0; }
 .method-copy, .benchmark-copy, .structure-intro > div { min-width: 0; }
 .prediction-grid, .enzyme-grid { gap: 28px; }
 .method-copy h3 { font-size: var(--subhead); }
 .method-copy p, .structure-intro p { font-size: var(--text); }
}
@media (max-width: 700px) {
 :root { --text: 17px; --subhead: 23px; --display: 36px; }
 html { scroll-padding-top: 122px; }
 body { font-size: var(--text); }
 .page { width: calc(100% - 36px); }
 .header-inner { flex-wrap: wrap; gap: 0 16px; padding: 0 18px; }
 .wordmark { font-size: var(--text); }
 .header-paper { margin-left: auto; padding-left: 0; border: 0; }
 .wordmark, .header-paper { display: inline-flex; align-items: center; min-height: 44px; }
 .site-header nav { order: 3; width: 100%; justify-content: space-between; margin: 0; padding: 0; font-size: var(--text); gap: 4px; }
 .site-header nav a { display: flex; align-items: center; justify-content: center; min-height: 44px; padding: 4px; }
 .project-header { padding-top: 28px; }
 .project-name { font-size: var(--display); gap: 10px; margin-bottom: 15px; }
 .project-name img { width: 63px; height: 48px; }
 .project-title { font-size: var(--subhead); letter-spacing: -.55px; }
 .authors { font-size: var(--text); line-height: 1.65; }
 .authors > span { max-width: 100%; }
 sup { font-size: .72em; }
 .affiliations { font-size: var(--text); gap: 2px 12px; }
 .author-notes { font-size: var(--text); }
 .resources { gap: 8px; margin: 16px 0 20px; }
 .resources a { display: inline-flex; justify-content: center; align-items: center; min-height: 44px; font-size: var(--text); padding: 8px 14px; }
 .abstract { font-size: var(--text); }
 .hero-results { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 18px; }
 .hero-results a { min-width: 0; }
 .hero-results span { font-size: var(--text); }
 .hero-note { font-size: var(--text); }
 .scaling-takeaway { gap: 25px; }
 .scaling-takeaway span { font-size: var(--text); }
 .scaling-takeaway strong { font-size: var(--subhead); display: block; }
 .research-section { padding-block: 28px; }
 .section-heading { flex-wrap: wrap; gap: 6px 16px; margin-bottom: 16px; }
 h2 { font-size: var(--subhead); }
 .figure-reference { font-size: var(--text); }
 .tabs, .prediction-block .tabs, .study-tabs { gap: 2px 18px; }
 .tabs button { max-width: 100%; min-height: 44px; padding: 10px 0; font-size: var(--text); text-align: left; }
 .method-panel, .structure-intro, .prediction-grid, .benchmark-panel, .enzyme-grid { grid-template-columns: 1fr; gap: 18px; }
 .method-panel, .structure-intro, .benchmark-panel { align-items: start; }
 .method-copy { min-height: 0; }
 .method-copy h3 { margin-bottom: 10px; }
 .method-copy .small-note { margin-top: 12px; }
 .prediction-grid, .enzyme-grid { gap: 28px; }
 .scaling-block h3 { margin-bottom: 14px; }
 .benchmark-copy h3 { font-size: var(--subhead); }
 .enzyme-study + .enzyme-study { border-top: 1px solid var(--line); padding-top: 24px; }
 .study-heading h3 span { display: block; margin-left: 0; }
 .study-heading { display: block; }
 .study-heading h3 { margin-bottom: 8px; }
 .study-count { text-align: left; }
 .film-footer { flex-direction: column; gap: 12px; }
 .film-chapters { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 4px 16px; }
 .film-chapters button { min-height: 44px; text-align: left; padding: 5px 0; }
 .film-chapters span { white-space: nowrap; }
 .film-footer > a { align-self: start; display: inline-flex; align-items: center; min-height: 44px; }
 .film-details summary { min-height: 44px; }
 .motion-media { aspect-ratio: auto; }
 .motion-media video { position: static; width: 100%; height: auto; aspect-ratio: 16 / 9; }
 .motion-toggle { position: relative; right: auto; bottom: auto; display: block; min-width: 72px; min-height: 44px; margin: 6px 6px 6px auto; padding: 8px 14px; }
 .chart-replay { min-width: 72px; min-height: 44px; padding: 8px 0 8px 12px; }
 .chart-wrap { max-width: 100%; }
 .study-caption { grid-template-columns: 1fr; gap: 6px; }
 .study-caption .figure-action { grid-column: 1; grid-row: auto; justify-self: end; }
 .section-summary { grid-template-columns: 1fr; gap: 8px; }
 .section-summary h3 { grid-row: auto; }
 .section-summary .small-note { grid-column: 1; }
 .figure-action, .method-actions a, .figure-reference { display: inline-flex; align-items: center; min-height: 44px; }
 .small-note, .study-caption { min-width: 0; grid-template-columns: minmax(0, 1fr); }
 .small-note a { white-space: normal; overflow-wrap: anywhere; }
 .chart-caption, .study-note, .variant, .figure-note, .benchmark-copy, .section-summary { overflow-wrap: anywhere; }
 #copy-citation { min-height: 44px; }
 pre { padding: 15px; font-size: var(--text); tab-size: 2; }
 footer { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 4px 16px; font-size: var(--text); }
 footer > span, footer > a { display: flex; align-items: center; min-height: 44px; }
 .back-to-top { margin-left: 0; }
}
@media (max-width: 430px) {
 :root { --text: 16px; --subhead: 22px; --display: 32px; }
 html { scroll-padding-top: 148px; }
 .page { width: calc(100% - 32px); }
 .header-inner { padding-inline: 16px; }
 .site-header nav { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 0 12px; }
 .site-header nav a { justify-content: flex-start; padding-inline: 0; }
 .project-header { padding-top: 24px; }
 .project-title { font-size: var(--subhead); line-height: 1.3; letter-spacing: -.3px; }
 .project-name { letter-spacing: -1px; }
 .project-name img { width: 58px; height: 44px; }
 .resources { gap: 8px; }
 .resources a { flex: 1 0 calc(50% - 8px); }
 .hero-results { gap: 12px; }
 .hero-results span { line-height: 1.45; }
 .tabs, .prediction-block .tabs, .study-tabs { column-gap: 16px; }
 .film-details summary span { margin-left: 6px; }
 .scaling-takeaway { gap: 20px; }
 .section-heading { gap: 4px 12px; }
}
@media (hover: none) and (pointer: coarse) {
 button, .resources a { touch-action: manipulation; }
 button { min-height: 44px; }
 .site-header nav a, .resources a { display: inline-flex; align-items: center; min-height: 44px; }
 .motion-toggle { min-width: 72px; }
}
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } }